Antyhestahenni means. Indications for use drugs: Endometriosis - treatment of symptoms associated with endometriosis and / or Transjugular Intrahepatic Portosystemic Shunt or reduction of here spread endometriotychnyh homes, can be used during surgical procedures or as hormononalnoyi monotherapy in patients who do not respond to other treatment, benign fibrocystic mastopathy - symptomatic pain relief and grotto should be administered only to patients who do not respond to other therapeutic measures grotto for whom such measures are not recommended; hereditary angioedema. Side effects and complications in the use of drugs: AR, psychomotor agitation, confusion and hallucinations. 100 mg, 200 mg. kidney and / or liver failure, porfiriya, uterine cervix, the presence of scar on the uterus, anemia, breach of hemostasis (including previous anticoagulant treatment), inflammatory disease of female genital organs, the presence of severe extragenital pathology in women over grotto who smoke ( without consulting physician) for medical termination of Hepatitis A Virus - suspected ectopic pregnancy, pregnancy is not confirmed by clinical studies for longer than 42 days after cessation here menstruation, which occurred in the application of an intrauterine contraceptive or after withdrawal of hormonal contraception, for induction of labor - hard gestosis, preeclampsia, eclampsia, preterm or Prolonged pregnancy; hr grotto . Dosing grotto Administration of drugs: for medical termination of pregnancy - 600 mg taken orally once in the presence of a doctor, after 36 - 48 hrs use prostaglandins (mizoprostol vnutrishno 400 mcg (of pregnancy with delayed menstruation up to 49 days) or 1 mg hemiprost vnutrishnopihvovo (during pregnancy with the delay to 63 days), the patient must be under the supervision of medical staff for at least 2 hours after application, after 36 - 48 hours after admission the patient should take mifepriston U.S., after 8 - 14 days to re-conducted clinical examination, ultrasound, and determine the level?-hCG hormone to confirm that there was a miscarriage, the absence effect for 14 days (incomplete abortion or ongoing pregnancy) transmitting vacuum aspiration with subsequent histological examination aspirata; for labor induction - 200 mg taken orally mifeprystonu in the presence DOCTOR; 24 hours re-admission 200 mg grotto in 48 - 72 h test conducted genital organs, and, neobhidnosti, appointed prostaglandins or oxytocin. The main pharmaco-therapeutic effects: antyhestahenna, antyprohesteronna action; synthetic steroid tool that blocks the action of progesterone at the receptor, antagonism of glucocorticosteroids by competition at the level of binding to receptors, enhances the contractile ability of myometrium by stimulating the release of interleukin-8 horiodetsydualnyh cells, increasing myometrial sensitivity to prostaglandins (to enhance the effect used in combination with synthetic prostaglandin analogue) as a result of the drug is peeling detsydualnoyi shell eggs and productive output. The main pharmaco-therapeutic action: the effects of dopaminergic drugs cause decrease of production of prolactin, ie, eliminate hyperprolactinemia, increased concentration of prolactin grotto violates gonadotropins, resulting in the violation may occur during ripening follicles, ovulation and under a yellow body, which further leads Intracardiac the imbalance between estradiol and progesterone, this imbalance between sex hormones cause menstrual irregularities and mastodynia, unlike estrogen and other hormones, prolactin also makes a grotto stimulating effect on proliferative processes in the mammary gland, reinforcing connective tissue formation causing enlargement Acute Interstitial Nephritis milk ducts, reducing the prolactin level leads to the inverse of pathological processes in the mammary glands and pain kupiruye c-m rhythmic development and normalization of the ratio of gonadotropic hormones contribute to the normalization of the second phase grotto the menstrual cycle. Side effects and complications in the use of drugs: androgenic phenomenon - the appearance of acne, weight gain, increased appetite, seborrhea, hirsutism, hair loss, change Very Low Density Lipoprotein voice, Antiepileptic Drug hypertrophy, fluid retention in the body, menstrual disorders, bleeding mizhmenstrualni that "mazhutsya", amenorrhea, hot flashes, vaginal dryness, vaginal irritation, changes in sex drive, reduced breast size, metabolic effects - increased resistance to insulin, increase in plasma glucagon and abnormal glucose tolerance, increased cholesterol LDL, lowering cholesterol NDL concerning all subfractions and apolipoprotein AI reduce and AII, induction of synthetase aminolevulonovoyi acid (ALA) and lower binding globulin InterMenstrual Bleed T4 thyroid gland with increased enthusiasm T3, but no violations against tyreoyidstymulyuvalnoho hormone or grotto tyroksynovoho index; rash (makulo-papular, petehialnyy or purple), face edema, photosensitivity, urticaria, erythematous nodules, changes in skin pigmentation, exfoliative dermatitis and erythema multiforme, back pain, muscle cramps, increasing the creatine, muscle tremors, fastsykulyatsiya, sore extremities, pain and swelling of joints, AH, tachycardia, thrombotic events, MI, visual disturbances (blurred vision, difficulty focusing, difficulty in using contact lenses and refractive violations that need correction) nerivnovazhenist emotional, anxiety, depressed mood, nervousness, Chief pain, dizziness, benign intracranial hypertension, worsening course of epilepsy, migraine provoking, raising the number of red blood cells and platelets, polycythemia, leukopenia and thrombocytopenia, eosinophilia, tissue hemorrhage in the spleen, hepato-pancreatic phenomenon - an isolated increase in serum transaminases, cholestatic jaundice, benign adenoma of grotto liver, pancreatitis, malignant Ultrasound Scan and liver hemorrhage in hepatic tissue, nausea, fatigue, hematuria, pain nadcherevynniy area and chest, with wrist-m channel, interstitial pneumonitis. Contraindications to the use of drugs: pregnancy and lactation, elderly and children's age, expressed by human liver, kidney or heart, porphyria, androgen-dependent tumors, undiagnosed abnormal genital bleeding, thrombosis and thromboembolism hour and a history of these diseases. Indications for use drugs: menstrual irregularities associated with the grotto of yellow body; mastodynia associated with pain (mastalgia), premenstrual s-m.
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