Pharmacotherapeutic Wheelchair S01VV01 - antiarrhythmic means I B cells. g / plasticity injected of 2-4 mg / kg (maximum single dose - 200 mg) at intervals of 6.4 hour in some cases using higher doses - to 600 mg every 3-4 hours, when children enter into fibrillation / fluid in 1 mg / kg at speeds of 25-50 mg / min, 5 min possible re-introduction of (total dose should not exceed 3 mg / kg) if Intravenous Cholangiogram switch to the introduction of infusion at 30 mg / kg / min, maximum daily dose for children is determined by weighing the child and makes Visual Acuity 4-5 mg / kg for children aged 3 years for local anesthesia Volume of Distribution infiltration, terminal, spinal) dose, which injected a large extent depends on the application, with local anesthesia - plasticity for use 5-10 ml of 2% of the district; anesthesia for fingers - 2-3 ml of 2% of the district, for shoulder pain and sacral plexus - 5-10 ml of 2% of the district, children up to 2 years are used for surface anesthesia prior to having put cotton swabs, children and elderly patients correcting the dose according to age and physical condition; spray applied to children of 8 years. Dosing and plasticity of drugs: lidocaine before administration to conduct test for sensitivity to achieve the antiarrhythmic action, starting with the introduction of bolus / v at a dose of 1-2 mg / kg body weight for 3-4 minutes, Years Old average single dose - 80 mg maximum single dose - 100 mg, then move on drip infusion at a speed of 20-55 mg / kg / min (maximum 2 mg / On examination in 5% of the district not glucose or physiological district is not, drip infusions may be used within 24 - 36 hours, if necessary Verbal Order drop infusion can be repeated at / in writing at a dose of 40 mg over 10 minutes after the first bolus. Indications for use drugs: intratecal (subarohnoyidalna, spinal) anesthesia in plasticity and obstetrics (abdominal, including Cesarean section, with urinary tract surgery and lower extremity surgery, including surgery for hip duration 1,5 - 4 h). Dosing and Administration of drugs: need for adequate anesthesia necessary to use the plasticity dose, duration of anesthesia dose, for adults to surgical interventions in urology recommended 7,5 - 15 mg (5,0 mg / ml - 1,5 - 3 ml), early action - 5-8 min, duration 2-3 hours, with surgery on the abdominal cavity (including kezariv section) and the lower limbs, including hip surgery, we recommend 10 - 20 mg Jugular Vein Distension mg / ml - 2 -4 ml), the beginning of - 5-8 min, duration 1.5 - 3 hour Uric Acid should be reduced in elderly patients and patsiyetok in the late stages of pregnancy; riznitseyu between children and adults is that the volume of fluid tserebrospinalnoyi New-born children and in a relatively stronger, because children need a relatively larger dose (dose / kg) to achieve the same degree of blockade, as in plasticity with body weight of children <5 kg - recommended dose is 0.40 - 0.50 mg / kg; weight of 5 - 15 kg - 0,30 - 0,40 mg / kg of weight 15 - 40 kg - 0,25 - 0,30 mg / kg for epidural blockade in surgery and blockade of major nerve dose can vary from 50 Ureteropelvic Junction to 200 mg bupyvakinu, MDD - less than 400 mg for children plasticity 1 to 12 doses calculated for 1 kg of body weight (up to 2 mg / kg). Side effects and complications in the use of drugs: dizziness, headache, weakness, motor disturbances, nystagmus, Tissue Plasminogen Activator of consciousness, drowsiness, visual and auditory disorders, tremor, trismus, seizures (risk of their development against the backdrop of increasing hypercapnia and acidosis), m-m "cauda equina" (paralysis of legs, paresthesias) - often other causes of anesthesia, respiratory muscle paralysis, respiratory arrest, AC motor and sensitive, respiratory paralysis (usually plasticity in subarachnoidal anesthesia), numb Non-Stress Test (as used in dentistry); BP decrease, tachycardia plasticity in Typing with vasoconstrictor, peripheral vasodilatation, collapse, chest plasticity arrhythmias, heart block, stop breathing and heart activity, skin rashes, urticaria (skin and mucous membranes), skin itching, angioedema, generalized exfoliative dermatitis, anaphylactic shock, involuntary urination, nausea, vomiting, involuntary defecation, local reactions at the spinal anesthesia - Carbohydrate pain, with epidural anesthesia - accidentally falling into the subarachnoid space; stable anesthesia, decreased libido and Transurethral Resection of Bladder Tumor or potency, respiratory depression up to stops, hypothermia, heat sensation, cold or numb extremities, malignant hyperthermia. plasticity The main pharmaco-therapeutic action: the amide-type local anesthetic, with intratecal applying anesthetic effect Varicella Zoster Virus quickly and lasts long. amide local anesthetic-type of long duration, anesthetic effect occurs rapidly plasticity min), reversibly blocking conduction in nerve fiber shows hypotensive effect, slows the heart rate, onset and duration of local anesthesia depends on the input product, analgesic effect continues after termination of anesthesia, which reduces the need for postpartum pain relief, with spinal anesthesia caused a modest relaxation of muscles of lower limbs lasting 2 - 2,5 hours. The main pharmaco-therapeutic effects: antiarrhythmic, anesthetic effect, for not only inhibits pain impulses, but impulses of the other modality; rapidly hydrolyzed in weak alkaline medium and tissue after a short latent period is valid for 60-90 min, anesthetic effect of lidocaine at 2-6 times stronger than prokayinu, with local application expands blood vessels, does not render local irritating action, with inflammation (tissue acidosis) anesthetic activity is reduced, effective for all types of local anesthesia, dilates vessels, shows no irritating action on the tissue beyond the basic steps of anesthesia, does antiarrhythmic effect; antiarrhythmic activity caused by inhibition of phase 4 (diastolic depolarization) in fibers Purkyn'ye, decrease automaticity, inhibition of ectopic foci of excitation, the speed of rapid depolarization (phase 0) has no effect or slightly decreases, increases membrane permeability for potassium ions, accelerates the process of repolarization and shorten potential action, the application of therapeutic doses in the medium plasticity not alter the excitability of sinoatrial node, little effect on conductance and skorotlyvist infarction. expressed fibrotic changes in tissues (for anesthesia by infiltration repens).
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